The Antiatherosclerotic effect of Bunapi

An overview of arteriosclerosis

Excess cholesterol in the bloodstream is a major cause of arteriosclerosis. Cholesterol builds up on the walls of bloodvessels, forming atherosclerotic plaque.

Blood vessels become more prone to clogging, and may be lead to issues such as: cardiac infarction, cerebral infarction/ stroke and aortic aneurysm.


Test Method and Results

Trials using arteriosclerotic model on mice

Either normal feed alone or a mixture of feed and bunapi (3%) was given to mice that are genetically disposed to developing arteriosclerosis for a period of 10 weeks. (Five mice per group.)

The heart and surrounding blood vessels of the mice

The suppression of atherosclerotic plaque with bunapi

Area painted with green; atherosclerotic lesion


The reduction of cholesterol levels due to bunapi



We conclude that bunapi can be expected to lower blood cholesterol levels, with the effect of suppressing arteriosclerosis.

Antiatherosclerotic effect of Bunapi / PDF

Hitoshi Ishida, Graduate School of Pharmaceutical Sciences, University of Shizuoka
Masahiko Ikeda, Graduate School of Health Sciences, University of Shizuoka
Mushroom laboratory, HOKUTO Corporation

Published in: Nutrition Research Volume 28, Issue 5, May 2008, Pages 335–342