Research
Pursuing the pharmacological effects and functions of mushrooms with a focus on health.
Our mushroom research center, Mushroom General Research Institute, is dedicated to researching beneficial pharmacological effects of mushrooms in order to use them to promote and maintaining healthy lifestyles.
We have already advanced research into a wide array of potential beneficial effects of mushrooms. Along with these efforts, we are striving to contribute to the life sciences through developing health foods and (functional foods) that feature mushrooms.
The results of our research are shown below.
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The Antiatherosclerotic effect of Bunapi
Excess cholesterol in the bloodstream is a major cause of arteriosclerosis. In this research, we conclude that bunapi can be expected to lower blood cholesterol levels, with the effect of suppressing arteriosclerosis.
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The Role of Mushrooms in the Promotion of Insulin Secretion
According to The NICHD, “Diabetes is one of the most common diseases in the United States, and its numbers are constantly rising.” In this reseach, we found that hot-water extracts of mushrooms may produce a strong effect on the promotion of insulin secretion. Especially notable results were seen with Bunashimeji, and Bunapi.
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The Role of Eryngii in Body Fat Reduction
We noted that eating King Trumpet mushrooms on a daily basis might be associated with reducing body weight, BMI, waist measurement, neutral fat in the blood and blood pressure which are indicators of metabolic syndrome.
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The Beneficial Effects of Eryngii on Constipation
We investigated the effects of bowel movements of women who have chronic constipation by having them ingest cooked King Trumpet mushrooms (eryngii).We concluded that an improvement in constipation can be expected by consuming King Trumpet mushrooms.
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The Anti-allergic Effects of Maitake
Our study has shown that Maitake mushrooms may have the potential to reduce allergy symptoms. In this research, Maitake mushroom extract can be expected to improve the symptoms of allergic reactions, such as hay fever.
List of all our research reports and studies
| Article title | Journal | Vol.，Page | Year |
|---|---|---|---|
| Pleurotus eryngii ameliorates lipopolysaccharide-induced lung inflammation in mice | Evidence-based complementary and alternative medicine | 2014, 1-7 | 2014 |
| Effects of Hericium erinaceus on amyloid beta(25-35) peptide-induced learning and memory dificits in mice | Biomedical research | 32, 67-72 | 2011 |
| Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice | J Nutr Sci Vitaminol | 56, 48-53 | 2010 |
| Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation | Phytomedicine | 17, 1082-1085 | 2010 |
| Rat medium-term multi-organ carcinogenesis bioassay of Agaricus blazei Murrill fruit-body extract | Food and chemical toxicology | 48, 402-408 | 2010 |
| Effects and safety of Pleurotus eryngii on body fat reduction in subjects with a body mass index between 24.5 and 35 kg/m2 | Jpn Pharmacol Ther | 38, 645-657 | 2010 |
| Endotoxin contamination of Agaricus blazei Murrill extract enhances murine immunologic responses and inhibits the growth of sarcoma 180 implants in vivo | J Environ Pathol Toxicol Oncol | 29, 159-168 | 2010 |
| Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial | Phytother Res | 23, 367-372 | 2009 |
| Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E–deficient mice | Nutrition research | 28, 335-342 | 2008 |
| Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells | Biol Pharm bull | 31, 1727-1732 | 2008 |
| Suppressive effect of Pleurotus eryngii extract on postprandial serum triacylglycerol elevation. (Japanese) | Jpn Pharmacol Ther | 36, 817-823 | 2008 |
| Hypotensive effects and safety of extracts squeezed from Agaricus blazei on high-normal blood pressure and mild hypertensive subjects. (Japanese) | Jpn Pharmacol Ther | 34, 1323-1341 | 2006 |
| The safety of excessive ingestion of Agaricus blazei in high-normal blood pressure persons. (Japanese) | Jpn Pharmacol Ther | 34, 1311-1321 | 2006 |
| Effect of extracts squeezed from Agaricus blazei for high-normal blood bressure or mild hypertension on human blood pressure. (Janapene) | Jpn Pharmacol Ther | 34, 1295-1309 | 2006 |
| The safety of normal and excessive ingestion of Agaricus blazei in healthy persons. (Japanese) | Jpn Pharmacol Ther | 34, 1247-1257 | 2006 |
| An acute single oral dose toxicity study of a compression extract of Agaricus blazei Murrill fruit-body in rats. (Japanese) | Pharmacometrics | 70, 93-95 | 2006 |
| A 90-day repeated oral toxicity study of the compression extract of Agaricus blazei Murrill fruit-body in rats. (Japanese) | Pharmacometrics | 71, 51-59 | 2006 |
| Micronucleus test for oral administration of a compression extract of Agaricus blazei Murrill fruit-body with mice. (Japanese) | Pharmacometrics | 71, 47-50 | 2006 |
| A 28-day repeat oral toxicity study of a compression extract of Agaricus blazei Murrill fruit-body in rats. (Japanese) | Pharmacometrics | 71, 37-46 | 2006 |